Selenoprotein P associates with endothelial cells in rat tissues

被引：78

作者：

Burk, RF ^{[1
]}

Hill, KE ^{[1
]}

Boeglin, ME ^{[1
]}

Ebner, FF ^{[1
]}

Chittum, HS ^{[1
]}

机构：

[1] VANDERBILT UNIV,INST DEV NEUROSCI,KENNEDY CTR,NASHVILLE,TN 37232

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 1997年 / 108卷 / 01期

关键词：

D O I：

10.1007/s004180050141

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Selenoprotein P is an extracellular heparin-binding protein that has been implicated in protecting the liver against oxidant injury. Its location in liver, kidney, and brain was determined by conventional immunohistochemistry and confocal microscopy using a polyclonal antiserum. Selenoprotein P is associated with endothelial cells in the liver and is more abundant in central regions than in portal regions. It is also present in kidney glomeruli associated with capillary endothelial cells. Staining of selenoprotein P in the brain is also confined to vascular endothelial cells. The heparin-binding properties of selenoprotein P could be the basis for its binding to tissue. Its localization to the vicinity of endothelial cells is potentially relevant to its oxidant defense function.

引用

页码：11 / 15

页数：5

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