Regenerative Pharmacology for Diabetes Mellitus

被引:1
作者
Furth, Mark E. [1 ]
Christ, George J. [1 ]
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA
关键词
EMBRYONIC STEM-CELLS; ISLET-LIKE CLUSTERS; BETA-CELL; SMALL-MOLECULE; DIFFERENTIATION; TRANSPLANTATION; GENERATION; MASS;
D O I
10.1124/mi.9.4.5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
[No abstract available]
引用
收藏
页码:171 / 174
页数:4
相关论文
共 23 条
[1]
Regenerative pharmacology - The future is now [J].
Andersson, Karl-Erik ;
Christ, George J. .
MOLECULAR INTERVENTIONS, 2007, 7 (02) :79-86
[2]
Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells [J].
Borowiak, Malgorzata ;
Maehr, Rene ;
Chen, Shuibing ;
Chen, Alice E. ;
Tang, Weiping ;
Fox, Julia L. ;
Schreiber, Stuart L. ;
Melton, Douglas A. .
CELL STEM CELL, 2009, 4 (04) :348-358
[3]
Regulation of pancreatic beta-cell mass [J].
Bouwens, L ;
Rooman, I .
PHYSIOLOGICAL REVIEWS, 2005, 85 (04) :1255-1270
[4]
A small molecule that directs differentiation of human ESCs into the pancreatic lineage [J].
Chen, Shuibing ;
Borowiak, Malgorzata ;
Fox, Julia L. ;
Maehr, Rene ;
Osafune, Kenji ;
Davidow, Lance ;
Lam, Kelvin ;
Peng, Lee F. ;
Schreiber, Stuart L. ;
Rubin, Lee L. ;
Melton, Douglas .
NATURE CHEMICAL BIOLOGY, 2009, 5 (04) :258-265
[5]
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation [J].
Dor, Y ;
Brown, J ;
Martinez, OI ;
Melton, DA .
NATURE, 2004, 429 (6987) :41-46
[6]
The clinical impact of islet transplantation [J].
Fiorina, P. ;
Shapiro, A. M. J. ;
Ricordi, C. ;
Secchi, A. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (10) :1990-1997
[7]
Functional analysis of a conditionally transformed pancreatic β-cell line [J].
Fleischer, N ;
Chen, C ;
Surana, M ;
Leiser, M ;
Rossetti, L ;
Pralong, W ;
Efrat, S .
DIABETES, 1998, 47 (09) :1419-1425
[8]
Stem Cell Sources to Treat Diabetes [J].
Furth, Mark E. ;
Atala, Anthony .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 106 (04) :507-511
[9]
The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets [J].
Hardy, LW ;
Peet, NP .
DRUG DISCOVERY TODAY, 2004, 9 (03) :117-126
[10]
Finding the target after screening the phenotype [J].
Hart, CP .
DRUG DISCOVERY TODAY, 2005, 10 (07) :513-519