Oct-4: The almighty POUripotent regulator?

被引：11

作者：

Buitrago, William

Roop, Dennis R.

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 02期

关键词：

D O I：

10.1038/sj.jid.5700654

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Oct-4 plays an essential role as a central regulator of the undifferentiated state. Grinnell et al. demonstrate for the first time that Oct-4 by itself has the ability to reprogram committed somatic cells, inducing their dedifferentiation by reverting them to a more developmentally potent state. This study provides evidence that Oct-4 might be the master regulator of the pluripotent state in mammalian cells.

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页码：260 / 262

页数：3

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