Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats

被引：20

作者：

Asha, V. V. ^{[1
]}

Sheeba, M. S. ^{[1
]}

Suresh, V. ^{[1
]}

Wills, P. J. ^{[1
]}

机构：

[1] Rajiv Gandhi Ctr Biotechnol, Mol Ethnopharmacol Lab, Thiruvananthapuram 695014, Kerala, India

来源：

FITOTERAPIA | 2007年 / 78卷 / 02期

关键词：

Phyllanthus maderaspatensis; carbon tetrachloride; thioacetamide; hepatoprotection; silymarin;

D O I：

10.1016/j.fitote.2006.10.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The hexane extract of Phyllanthus maderaspatensis (200 and 100 mg/kg) showed significant hepatoprotection on carbon tetrachloride and thioacetamide induced liver damage in rats. The protective effect was evident from serum biochemical parameters and histopathological analysis. Rats treated with P maderaspatensis remarkably prevented the elevation of serum AST, ALT and LDH and liver lipid peroxides in CCl4 and thioacetamide treated rats. Hepatic glutathione levels significantly increased by the treatment with the extracts. Histopathological changes induced by CCl4 and thioacetamide were also significantly reduced by the extract treatment. The activity of hexane extracts of P. maderaspatensis was comparable to that of silymarin, the reference hepatoprotective drug. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：134 / 141

页数：8

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