Cancer - New link in a web of human genes

被引：31

作者：

Wang, JYJ ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA

来源：

NATURE | 2000年 / 405卷 / 6785期

关键词：

D O I：

10.1038/35013171

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

ATM and NBS1 are genes that are mutated in two different human diseases. Cells from patients with these diseases show similarities, including increased chromosome breakage, so ATM and NBS1 might work together in DNA repair. Indeed, ATM phosphorylates NBS1 in several places — events needed for the cellular response to DNA breaks.

引用

页码：404 / 405

页数：2

共 16 条

[1] Enhanced phosphorylation of p53 by ATN in response to DNA damage [J].

Banin, S ;

Moyal, L ;

Shieh, SY ;

Taya, Y ;

Anderson, CW ;

Chessa, L ;

Smorodinsky, NI ;

Prives, C ;

Reiss, Y ;

Shiloh, Y ;

Ziv, Y .

SCIENCE, 1998, 281 (5383) :1674-1677

[2] Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome [J].

Bell, DW ;

Varley, JM ;

Szydlo, TE ;

Kang, DH ;

Wahrer, DCR ;

Shannon, KE ;

Lubratovich, M ;

Verselis, SJ ;

Isselbacher, KJ ;

Fraumeni, JF ;

Birch, JM ;

Li, FP ;

Garber, JE ;

Haber, DA .

SCIENCE, 1999, 286 (5449) :2528-2531

[3] Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 [J].

Canman, CE ;

Lim, DS ;

Cimprich, KA ;

Taya, Y ;

Tamai, K ;

Sakaguchi, K ;

Appella, E ;

Kastan, MB ;

Siliciano, JD .

SCIENCE, 1998, 281 (5383) :1677-1679

[4]

Chehab NH, 2000, GENE DEV, V14, P278

[5] Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system [J].

Chong, MJ ;

Murray, MR ;

Gosink, EC ;

Russell, HRC ;

Srinivasan, A ;

Kapsetaki, M ;

Korsmeyer, SJ ;

McKinnon, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :889-894

[6] Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks [J].

Cortez, D ;

Wang, Y ;

Qin, J ;

Elledge, SJ .

SCIENCE, 1999, 286 (5442) :1162-1166

[7] ATM-dependent phosphorylation of nibrin in response to radiation exposure [J].

Gatei, M ;

Young, D ;

Cerosaletti, KM ;

Desai-Mehta, A ;

Spring, K ;

Kozlov, S ;

Lavin, MF ;

Gatti, RA ;

Concannon, P ;

Khanna, K .

NATURE GENETICS, 2000, 25 (01) :115-119

[8] DNA damage-induced activation of p53 by the checkpoint kinase Chk2 [J].

Hirao, A ;

Kong, YY ;

Matsuoka, S ;

Wakeham, A ;

Ruland, J ;

Yoshida, H ;

Liu, D ;

Elledge, SJ ;

Mak, TW .

SCIENCE, 2000, 287 (5459) :1824-1827

[9] hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response [J].

Lee, JS ;

Collins, KM ;

Brown, AL ;

Lee, CH ;

Chung, JH .

NATURE, 2000, 404 (6774) :201-204

[10] ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway [J].

Lim, DS ;

Kim, ST ;

Xu, B ;

Maser, RS ;

Lin, JY ;

Petrini, JHJ ;

Kastan, MB .

NATURE, 2000, 404 (6778) :613-+

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