Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors

被引：59

作者：

Kwon, BM ^{[1
]}

Lee, SH ^{[1
]}

Cho, YK ^{[1
]}

Bok, SH ^{[1
]}

So, SH ^{[1
]}

Youn, MR ^{[1
]}

Chang, SI ^{[1
]}

机构：

[1] CHUNGBUK NATL UNIV,COLL NAT SCI,DEPT BIOCHEM,CHEONGJU 361763,SOUTH KOREA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(97)10008-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-hydroxycinnamaldehyde derivatives was synthesized for examing a structure-activity relationship for inhibition of angiogenesis. The anti-angiogenic effects of 2'-substituted cinnamaldehdes and related analogs were determined in a chick embryo chorioallantoic membrane assay system. (C) 1997 Elsevier Science Ltd.

引用

页码：2473 / 2476

页数：4

共 9 条

[1] Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways [J].

Arbiser, JL ;

Moses, MA ;

Fernandez, CA ;

Ghiso, N ;

Cao, YH ;

Klauber, N ;

Frank, D ;

Brownlee, M ;

Flynn, E ;

Parangi, S ;

Byers, HR ;

Folkman, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (03) :861-866

[2] ANGIOGENESIS INHIBITION - A REVIEW [J].

AUERBACH, W ;

AUERBACH, R .

PHARMACOLOGY & THERAPEUTICS, 1994, 63 (03) :265-311

[3] Synthesis and antiangiogenic activity of new carbohydrate derivatives [J].

Dorey, G ;

Leon, P ;

Sciberras, S ;

Leonce, S ;

Guilbaud, N ;

Pierre, A ;

Atassi, G ;

Billington, DC .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (24) :3045-3050

[4] CONTROLLING THE VASCULATURE - ANGIOGENESIS, ANTI-ANGIOGENESIS AND VASCULAR TARGETING OF GENE-THERAPY [J].

FAN, TPD ;

JAGGAR, R ;

BICKNELL, R .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1995, 16 (02) :57-66

[5] GENISTEIN, A DIETARY-DERIVED INHIBITOR OF INVITRO ANGIOGENESIS [J].

FOTSIS, T ;

PEPPER, M ;

ADLERCREUTZ, H ;

FLEISCHMANN, G ;

HASE, T ;

MONTESANO, R ;

SCHWEIGERER, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :2690-2694

[6] POTENT ANTI-ANGIOGENIC ACTION OF AGM-1470 - COMPARISON TO THE FUMAGILLIN PARENT [J].

KUSAKA, M ;

SUDO, K ;

FUJITA, T ;

MARUI, S ;

ITOH, F ;

INGBER, D ;

FOLKMAN, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 174 (03) :1070-1076

[7] 2'-hydroxycinnamaldehyde from stem bark of Cinnamomum cassia [J].

Kwon, BM ;

Cho, YK ;

Lee, SH ;

Nam, JY ;

Bok, SH ;

Chun, SK ;

Kim, JA ;

Lee, IR .

PLANTA MEDICA, 1996, 62 (02) :183-184

[8] CANCER METASTASIS AND ANGIOGENESIS - AN IMBALANCE OF POSITIVE AND NEGATIVE REGULATION [J].

LIOTTA, LA ;

STEEG, PS ;

STETLERSTEVENSON, WG .

CELL, 1991, 64 (02) :327-336

[9] Manipulating angiogenesis - From basic science to the bedside [J].

Pepper, MS .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (04) :605-619

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