A straightforward detection of deprotonated conformers of malonic acid by solid-state 13C NMR spectroscopy

被引：12

作者：

Colsenet, R

Gardiennet, C

Henry, B

Tekely, P ^{[1
]}

机构：

[1] Univ H Poincare Nancy 1, FRE 2415, CNRS, Lab Methodol RMN, F-54500 Vandoeuvre Les Nancy, France

[2] Univ H Poincare Nancy 1, Lab Chim Phys Organ & Colloidale, UMR 7565, CNRS, F-54500 Vandoeuvre Les Nancy, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 24期

关键词：

D O I：

10.1002/anie.200290035

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Information about the presence and the nature of various deprotonated forms of malonic acid in lyophilizates prepared from parent solutions at different pH values can be obtained by solid-state, natural abundance 13C NMR spectroscopy, particularly if a 13C-enriched substrate is used (see picture). pK values calculated from solid-state acid:base ratios are found to be equal to those classically measured in the liquid state.

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页码：4743 / 4745

页数：3

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