Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats

被引：50

作者：

Kline, AE

Yu, JY

Massucci, JL

Zafonte, RD

Dixon, CE

机构：

[1] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15260 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 333卷 / 03期

关键词：

8-hydroxy-2-(di-n-propylamino)tetralin; controlled cortical impact; Morris water maze; recovery; spatial learning and memory;

D O I：

10.1016/S0304-3940(02)01101-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To further investigate the efficacy of 5-HT1A receptor agonism on functional and histological outcome in traumatically-brain injured (TBI) rats, a single intraperitoneal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.1, 0.5, or 1.0 mg/kg) or vehicle was given 15 min after controlled cortical impact or sham injury. Function was assessed by established motor and cognitive tests on post-operative days 1-5 and 14-18, respectively. Cortical lesion volume and hippocampal CA(1)/CA(3) cell survival were quantified at 4 weeks. The administration of 8-OH-DPAT (0.5 mg/kg) attenuated spatial acquisition deficits and reduced hippocampal CA(3) cell loss vs. vehicle (P < 0.05). These data augment published reports that 5-HT1A receptor agonists confer neuroprotective effects after experimental TBI. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：179 / 182

页数：4

共 17 条

[1] ELECTROPHYSIOLOGY OF 5-HT(1A) RECEPTORS IN THE RAT HIPPOCAMPUS AND CORTEX [J].