Simplified preparation of the ginsenoside-Rh-2 minor saponin from ginseng

被引：33

作者：

Atopkina, LN ^{[1
]}

Uvarova, NI ^{[1
]}

Elyakov, GB ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,PACIFIC INST BIOORGAN CHEM,FAR E DIV,VLADIVOSTOK 690022,RUSSIA

来源：

CARBOHYDRATE RESEARCH | 1997年 / 303卷 / 04期

关键词：

ginseng; ginsenoside; saponin; birch; cytotoxicity;

D O I：

10.1016/S0008-6215(97)00184-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Condensation of the 12-O-acetylderivative of 20(S)-protopanaxadiol [dammar-24-ene-3 beta,12 beta,20(S)-triol] with tetra-O-acetyl-alpha-D-glucopyranosyl bromide in the presence of silver oxide in dichloroethane, followed by deprotection with sodium methoxide in methanol, results in formation of the 3-O-beta-D-glucopyranosyldammar-24-ene-3 beta,12 beta,20(S)-triol identical with natural ginsenoside-Rh-2. The 12-O-acetyl-20(S)-protopanaxadiol is easily prepared from betulafolienetriol via the 3-keto-12-O-acetylderivative followed by NaBH4 reduction. This comparatively simple five-step synthesis makes this hitherto rare ginsenoside relatively accessible. (C) 1997 Elsevier Science Ltd.

引用

页码：449 / 451

页数：3