A facile solution and solid phase synthesis of phosphotyrosine mimetic L-4-[diethylphosphono(difluoromethyl)]-phenylalanine (F(2)Pmp(EtO)(2)) derivatives

被引：27

作者：

Qabar, MN ^{[1
]}

Urban, J ^{[1
]}

Kahn, M ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT PATHOBIOL, SEATTLE, WA 98195 USA

来源：

TETRAHEDRON | 1997年 / 53卷 / 32期

关键词：

D O I：

10.1016/S0040-4020(97)00374-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The F(2)Pmp derivatives were prepared in 80-90% yield from commercially available protected L-l-iodophenylalanine by esterification with diazomethane followed by a CuCl-mediated coupling to (diethylphosphonyl) difluoromethylcadmium bromide. Moreover, treatment of L-4-iodoPhe-containing peptides under the same coupling conditions provided the F,Pmp-containing peptides in very good yields. (C) 1997 Elsevier Science Ltd.

引用

页码：11171 / 11178

页数：8

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