A guide to murine coagulation factor structure, function, assays, and genetic alterations

被引：32

作者：

Emeis, J. J.

Jirouskova, M.

Muchitsch, E. -M.

Shet, A. S.

Smyth, S. S.

Johnson, G. J.

机构：

[1] VA Med Ctr, Minneapolis, MN 55417 USA

[2] TNO Prevent & Hlth, Leiden, Netherlands

[3] Rockefeller Univ, Lab Blood & Vasc Biol, New York, NY 10021 USA

[4] Baxter BioSci, Global Preclin R&D, BioPharmaceut, Vienna, Austria

[5] Univ Kentucky, Gill Heart Inst, Div Cardiovasc Med, Lexington, KY USA

[6] Univ Minnesota, Minneapolis, MN 55455 USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2007年 / 5卷 / 04期

关键词：

D O I：

10.1111/j.1538-7836.2007.02408.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful experimental models for evaluation of the pathophysiology and treatment of thrombosis. This review contains recommendations for obtaining, processing and assaying mouse blood hemostatic components, and it summarizes the extensive literature on murine coagulation factor structure and function, assays and genetic alteration. It is intended to be a convenient reference source for investigators of hemostasis and thrombosis.

引用

收藏

页码：670 / 679

页数：10

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