Oral contraceptives and the risk of multiple sclerosis: A review of the epidemiologic evidence

被引：33

作者：

Alonso, Alvaro ^{[1
,2
]}

Clark, Cari Jo ^{[3
]}

机构：

[1] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55416 USA

[2] Univ Navarra, Dept Prevent Med & Publ Hlth, Sch Med, E-31080 Pamplona, Spain

[3] Univ Minnesota, Dept Med, Sch Med, Minneapolis, MN 55416 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2009年 / 286卷 / 1-2期

关键词：

Oral contraceptive; Multiple sclerosis; Epidemiology; Estrogens; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PRACTICE RESEARCH DATABASE; CENTRAL-NERVOUS-SYSTEM; DIAGNOSTIC-CRITERIA; PREGNANCY; CYTOKINE; MICE; RECRUITMENT; EXPRESSION; GUIDELINES;

D O I：

10.1016/j.jns.2009.04.038

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) is more frequent in women than in men, suggesting that sex hormones could play a role in the development of MS. For this reason, several studies have assessed whether use of oral contraceptives modifies the risk of MS. In this article, we review the methodology and results of published epidemiologic studies addressing this issue. On the whole, the existing epidemiologic evidence does not support an important effect of oral contraceptive use on the risk of MS, though it does suggest that oral contraceptives might delay the onset of the disease. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：73 / 75

页数：3

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