Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex

被引:48
作者
Huether, G
Zhou, D
Schmidt, S
Wiltfang, J
Ruther, E
机构
[1] Department of Psychiatry, University of Göttingen, Göttingen
[2] Department of Psychiatry, University of Göttingen, 37075 Göttingen
关键词
anorexia; eating disorders; food restriction; paroxetine binding; serotonin transporter; starvation;
D O I
10.1016/S0006-3223(96)00265-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The influence of feeding rats only half the amount of their normal daily intake of a complete rat chow on the affinity and the density of serotonin (5-HT) transporters was measured in membrane preparations of the frontal cortex and the midbrain by a [H-3]paroxetine binding assay. In young rats (10 weeks), a significant reduction of about 30% of the B-max values of [H-3]paroxetine binding occurred in the frontal cortex after 1 and 2 weeks of restricted food intake. No starvation-induced decline of the density of 5-HT transporters was seen in the midbrain. When older rats (50 weeks) were subjected to the same 50% reduction of daily food intake for 2 weeks, no such down-regulation of the density of cortical 5-HT transporters was observed. The affinity of the 5-HT transporters, as indicated by the unchanged K-d values of [H-3]paroxetine binding, was not affected by semistarvation in both regions and at both ages. The observed decline of [H-3]paroxetine binding sites in the frontal cortex of young adult rats is the first demonstration of long-term regulatory phenomena of brain 5-HT transporters triggered by a physiologic stimulus. (C) 1997 Society of Biological Psychiatry.
引用
收藏
页码:1174 / 1180
页数:7
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