Persistence of an atherogenic lipid profile after treatment of acute infection with brucella

被引:37
作者
Apostolou, F. [1 ]
Gazi, I. F. [1 ]
Kostoula, A. [2 ]
Tellis, C. C. [3 ]
Tselepis, A. D. [3 ]
Elisaf, M. [1 ]
Liberopoulos, E. N. [1 ]
机构
[1] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece
[2] Univ Ioannina, Univ Hosp Ioannina, Dept Microbiol, GR-45110 Ioannina, Greece
[3] Univ Ioannina, Dept Chem, Biochem Lab, Ioannina, Greece
关键词
small dense low density lipoprotein; cytokines; lipoprotein-associated phospholipase A(2); paraoxonase; 1; cholesterol ester transfer protein; oxidized low density lipoprotein; PLATELET-ACTIVATING-FACTOR; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; ACUTE-PHASE RESPONSE; IMMUNODEFICIENCY-VIRUS-INFECTION; SYSTEMIC INFLAMMATORY RESPONSE; SERUM PARAOXONASE-1 ACTIVITY; II PHOSPHOLIPASE A(2); FACTOR-ACETYLHYDROLASE; HELICOBACTER-PYLORI;
D O I
10.1194/jlr.P900063-JLR200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Serum lipid changes during infection may be associated with atherogenesis. No data are available on the effect of Brucellosis on lipids. Lipid parameters were determined in 28 patients with Brucellosis on admission and 4 months following treatment and were compared with 24 matched controls. Fasting levels of total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides, apolipoproteins (Apo) A, B, E CII, and CIII, and oxidized LDL (oxLDL) were measured. Activities of serum cholesterol ester transfer protein (CETP), paraoxonase 1 (PON1), and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and levels of cytokines [interleukins (IL)-1 beta, IL-6, and tumor necrosis factor (TNFa)] were also determined. On admission, patients compared with controls had 1) lower levels of TC, HDL-C, LDL-cholesterol (LDL-C), ApoB, ApoAI, and ApoCIII and higher LDL-C/HDL-C and ApoB/ApoAI ratios; 2) higher levels of IL-1b, IL-6, and TNFa; 3) similar ApoCII and oxLDL levels and Lp-PLA(2) activity, lower PON1, and higher CETP activity; and 4) higher small dense LDL-C concentration. Four months later, increases in TC, HDL-C, LDL-C, ApoB, ApoAI, and ApoCIII levels, ApoB/ApoAI ratio, and PON1 activity were noticed compared with baseline, whereas CETP activity decreased. LDL-C/HDL-C ratio, ApoCII, and oxLDL levels, Lp-PLA(2) activity, and small dense LDL-C concentration were not altered. Brucella infection is associated with an atherogenic lipid profile that is not fully restored 4 months following treatment.-Apostolou, F., I. F. Gazi, A. Kostoula, C. C. Tellis, A. D. Tselepis, M. Elisaf, and E. N. Liberopoulos. Persistence of an atherogenic lipid profile after treatment of acute infection with brucella. J. Lipid Res. 2009. 50: 2532-2539.
引用
收藏
页码:2532 / 2539
页数:8
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