The effect of growth hormone (GH) on histomorphometric indices of bone structure and bone turnover in GH-deficient men

被引:68
作者
Bravenboer, N
Holzmann, P
DeBoer, H
Roos, JC
VanderVeen, EA
Lips, P
机构
[1] VRIJE UNIV AMSTERDAM, ACAD HOSP, DEPT ENDOCRINOL, NL-1007 MB AMSTERDAM, NETHERLANDS
[2] VRIJE UNIV AMSTERDAM, ACAD HOSP, DEPT NUCL MED, NL-1007 MB AMSTERDAM, NETHERLANDS
[3] ACAD CTR DENT AMSTERDAM, DEPT ORAL CELL BIOL, NL-1081 BT AMSTERDAM, NETHERLANDS
关键词
D O I
10.1210/jc.82.6.1818
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We investigated the effects of GH on bone structure and turnover by histomorphometry in GH-deficient adults. Therefore, transiliac bone biopsies were obtained before and after 1 yr of treatment in 36 GH-deficient men (mean age, 28 +/- 4 yr). Thirteen patients had isolated GH deficiency and 23 patients had multiple pituitary hormone deficiencies. Patients were randomly assigned to four treatment groups. Groups 1, 2, and 3 received 1, 2, and 3 IU/m(2)/day (2.9, 5.0, and 8.7 mg/m(2)/day) GH, respectively, and the fourth group received placebo for the first 6 months and 2 IU/m(2)/day (5.8 mg/m(2)/day) GH for the subsequent 6 months. GH treatment resulted in an increase of cortical thickness from 0.98 +/- 0.27 to 1.20 +/- 0.35 mm (P = 0.005), but trabecular bone volume did not change. Bone formation variables increased significantly: osteoid surface increased from 8.5 +/- 5.3 to 15.5 +/- 6.1% (P = 0.0002), mineralizing surface increased from 6.7 +/- 2.5 to 10.8 +/- 4.4% (P = 0.0002), and bone formation rate increased from 0.04 +/- 0.02 to 0.08 +/- 0.04 mm(3)/mm(2)/day (P = 0.0001). Eroded surface did not change, but osteoclast number increased from 0.6 +/- 0.5 to 1.25 +/- 0.5 Oc/mm(2) (P = 0.0001). The relative formation period increased significantly (P = 0.001), whereas the resorption period, including reversal phase, decreased from 65 to 40 days (P = 0.02). Activation frequency increased from 0.39 +/- 0.17 to 0.74 +/- 0.34 y(-1) (P = 0.0001). These data indicate a stimulated bone turnover as a result of GH treatment and a shorter resorption and reversal time. The increased turnover did not result in an increased trabecular bone volume, but the cortical thickness increased significantly.
引用
收藏
页码:1818 / 1822
页数:5
相关论文
共 22 条
[1]  
Andreassen TT, 1996, J BONE MINER RES, V11, P1094
[2]   THE EFFECTS OF PROLONGED GROWTH-HORMONE REPLACEMENT ON BONE METABOLISM AND BONE-MINERAL DENSITY IN HYPOPITUITARY ADULTS [J].
BESHYAH, SA ;
KYD, P ;
THOMAS, E ;
FAIRNEY, A ;
JOHNSTON, DG .
CLINICAL ENDOCRINOLOGY, 1995, 42 (03) :249-254
[3]   Histomorphometric analysis of bone mass and bone metabolism in growth hormone deficient adult men [J].
Bravenboer, N ;
Holzmann, P ;
deBoer, H ;
Blok, GJ ;
Lips, P .
BONE, 1996, 18 (06) :551-557
[4]   AN IMPROVED METHOD FOR EMBEDDING HARD TISSUE IN POLY(METHYL METHACRYLATE [J].
BUIJS, R ;
DOGTEROM, AA .
STAIN TECHNOLOGY, 1983, 58 (03) :135-141
[5]   THE OPTIMAL-GROWTH HORMONE REPLACEMENT DOSE ADULTS, DERIVED FROM BIOIMPEDANCE ANALYSIS [J].
DEBOER, H ;
BLOK, GJ ;
VOERMAN, B ;
DEVRIES, P ;
POPPSNIJDERS, C ;
VANDERVEEN, E .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (07) :2069-2076
[6]   Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers [J].
deBoer, H ;
Blok, GJ ;
PoppSnijders, C ;
Stuurman, L ;
Baxter, RC ;
vanderVeen, E .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (04) :1371-1377
[7]  
DEBOER H, 1994, J BONE MINER RES, V9, P1319
[8]   POTENT EFFECT OF RECOMBINANT GROWTH-HORMONE ON BONE-MINERAL DENSITY AND BODY-COMPOSITION IN ADULTS WITH PANHYPOPITUITARISM [J].
DEGERBLAD, M ;
ELGINDY, N ;
HALL, K ;
SJOBERG, HE ;
THOREN, M .
ACTA ENDOCRINOLOGICA, 1992, 126 (05) :387-393
[9]   EFFECTS OF RHIGF-I ADMINISTRATION ON BONE TURNOVER DURING SHORT-TERM FASTING [J].
GRINSPOON, SK ;
BAUM, HBA ;
PETERSON, S ;
KLIBANSKI, A .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (02) :900-906
[10]   ILIAC CREST BONE MASS AND REMODELING IN ACROMEGALY [J].
HALSE, J ;
MELSEN, F ;
MOSEKILDE, L .
ACTA ENDOCRINOLOGICA, 1981, 97 (01) :18-22