Coffee consumption and risk of type 2 diabetes mellitus

被引：331

作者：

van Dam, RM ^{[1
]}

Feskens, EJM ^{[1
]}

机构：

[1] Natl Inst Publ Hlth & Environm, Dept Chron Dis Epidemiol, NL-3720 BA Bilthoven, Netherlands

来源：

LANCET | 2002年 / 360卷 / 9344期

关键词：

D O I：

10.1016/S0140-6736(02)11436-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coffee is a major source of caffeine, which has been shown to acutely reduce sensitivity to insulin, but also has potentially beneficial effects. We prospectively investigated the association between coffee consumption and risk of clinical type 2 diabetes in a population-based cohort of 17 111 Dutch men and women aged 30-60 years. During 125 774 person years of follow-up, 306 new cases of type 2 diabetes were reported. After adjustment for potential confounders, individuals who drank at least seven cups of coffee a day were 0-50 (95% CI 0.35-0.72, p=0.0002) times as likely as those who drank two cups or fewer a day to develop type 2 diabetes. Coffee consumption was associated with a substantially lower risk of clinical type 2 diabetes.

引用

页码：1477 / 1478

页数：2

共 9 条

[1] Chlorogenic acid and hydroxynitrobenzaldehyde: New inhibitors of hepatic glucose 6-phosphatase [J].

Arion, WJ ;

Canfield, WK ;

Ramos, FC ;

Schindler, PW ;

Burger, HJ ;

Hemmerle, H ;

Schubert, G ;

Below, P ;

Herling, AW .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 339 (02) :315-322

[2]

Clifford MN, 2000, J SCI FOOD AGR, V80, P1033, DOI [10.1002/(SICI)1097-0010(20000515)80:7<1033::AID-JSFA595>3.0.CO

[3]

2-T, 10.1002/(SICI)1097-0010(20000515)80:7&lt

[4]

1033::AID-JSFA595&gt

[5]

3.0.CO

[6]

2-T]

[7] Caffeine can decrease insulin sensitivity in humans [J].

Keijzers, GB ;

De Galan, BE ;

Tack, CJ ;

Smits, P .

DIABETES CARE, 2002, 25 (02) :364-369

[8]

NAISMITH DJ, 1970, NUTR METAB, V12, P144

[9] Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women [J].

Salmeron, J ;

Manson, JE ;

Stampfer, MJ ;

Colditz, GA ;

Wing, AL ;

Willett, WC .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (06) :472-477

← 1 →