Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

被引：134

作者：

Fluck, Michele M. ^{[1
]}

Schaffhausen, Brian S. ^{[2
]}

机构：

[1] Michigan State Univ, Dept Microbiol & Mol Genet, Interdept Program Cell & Mol Biol, E Lansing, MI 48824 USA

[2] Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USA

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2009年 / 73卷 / 03期

关键词：

PROTEIN PHOSPHATASE 2A; MAMMARY-GLAND DEVELOPMENT; SIZED TUMOR-ANTIGEN; GROWTH-FACTOR RECEPTORS; HUMAN BREAST-CANCER; PHOSPHATIDYLINOSITOL KINASE-ACTIVITY; TYROSINE PHOSPHORYLATION SITES; TRANSFORMED RAT-CELLS; ROUS-SARCOMA VIRUS; PHOSPHOTYROSINE-BINDING DOMAIN;

D O I：

10.1128/MMBR.00009-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The small DNA tumor viruses have provided a very long-lived source of insights into many aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on cancer-related signaling. Here we review murine polyomavirus middle T antigen, its mechanisms, and its downstream pathways of transformation. We concentrate on the MMTV-PyMT transgenic mouse, one of the most studied models of breast cancer, which permits the examination of in situ tumor progression from hyperplasia to metastasis.

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页码：542 / +

页数：23

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