An annulative approach to highly substituted indoles: Unusual effect of phenolic additives on the success of the arylation of ketone enolates

被引：166

作者：

Rutherford, JL ^{[1
]}

Rainka, MP ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 51期

关键词：

D O I：

10.1021/ja0288993

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel palladium-catalyzed arylation of ketone enolates with o-nitrohaloarenes was achieved through the addition of phenol additives. The mild reaction conditions employed allowed for the inclusion of a wide variety of functional groups in both substrates to be tolerated. The products of this reaction were then readily reductively cyclized to give highly substituted indoles in moderate to excellent overall yields. Copyright © 2002 American Chemical Society.

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页码：15168 / 15169

页数：2

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