TIM-3 in autoimmunity

被引：97

作者：

Anderson, Ana C.

Anderson, David E.

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2006年 / 18卷 / 06期

关键词：

D O I：

10.1016/j.coi.2006.09.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell immunoglobulin and mucin domain (TIM)-3 is a molecule expressed on terminally differentiated murine Th1 cells but not on Th2 cells. Identification of galectin-9 as a ligand for TIM-3 has now firmly established the TIM-3-galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. TIM-3 is similarly expressed on human Th1 cells and not on Th2 cells, which suggests that TIM-3 might also contribute to Th1 regulation in humans. In addition, genetic data associate the TIM locus and specific TIM-3 polymorphisms with various immune-mediated diseases. Most importantly, recent data suggest a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis.

引用

收藏

页码：665 / 669

页数：5

相关论文

共 29 条

[21] Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance [J].

Sabatos, CA ;

Chakravarti, S ;

Cha, E ;

Schubart, A ;

Sánchez-Fueyo, A ;

Zheng, XX ;

Coyle, AJ ;

Strom, TB ;

Freeman, GJ ;

Kuchroo, VK .

NATURE IMMUNOLOGY, 2003, 4 (11) :1102-1110

[22] Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance [J].

Sánchez-Fueyo, A ;

Tian, J ;

Picarella, D ;

Domenig, C ;

Zheng, XX ;

Sabatos, CA ;

Manlongat, N ;

Bender, O ;

Kamradt, T ;

Kuchroo, VK ;

Gutiérrez-Ramos, JC ;

Coyle, AJ ;

Strom, TB .

NATURE IMMUNOLOGY, 2003, 4 (11) :1093-1101

[23] A ROLE FOR NON-MHC GENETIC-POLYMORPHISM IN SUSCEPTIBILITY TO SPONTANEOUS AUTOIMMUNITY [J].

SCOTT, B ;

LIBLAU, R ;

DEGERMANN, S ;

MARCONI, LA ;

OGATA, L ;

CATON, AJ ;

MCDEVITT, HO ;

LO, D .

IMMUNITY, 1994, 1 (01) :73-82

[24] FUNCTIONAL DIVERSITY OF LYMPHOCYTE-T DUE TO SECRETION OF DIFFERENT CYTOKINE PATTERNS [J].

STREET, NE ;

MOSMANN, TR .

FASEB JOURNAL, 1991, 5 (02) :171-177

[25]

SWAIN SL, 1990, J IMMUNOL, V145, P3796

[26] A targeted DNA vaccine augments the natural immune response to self TNF-α and suppresses ongoing adjuvant arthritis [J].

Wildbaum, G ;

Youssef, S ;

Karin, N .

JOURNAL OF IMMUNOLOGY, 2000, 165 (10) :5860-5866

[27] EXPRESSION OF COSTIMULATORY MOLECULES B7-1 (CD80), B7-2 (CD86), AND INTERLEUKIN-12 CYTOKINE IN MULTIPLE-SCLEROSIS LESIONS [J].

WINDHAGEN, A ;

NEWCOMBE, J ;

DANGOND, F ;

STRAND, C ;

WOODROOFE, MN ;

CUZNER, ML ;

HAFLER, DA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1985-1996

[28] C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis [J].

Youssef, S ;

Maor, G ;

Wildbaum, G ;

Grabie, N ;

Gour-Lavie, A ;

Karin, N .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (03) :361-371

[29] The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity [J].

Zhu, C ;

Anderson, AC ;

Schubart, A ;

Xiong, HB ;

Imitola, J ;

Khoury, SJ ;

Zheng, XX ;

Strom, TB ;

Kuchroo, VK .

NATURE IMMUNOLOGY, 2005, 6 (12) :1245-1252