Synaptic Linkages Between Corticomotoneuronal Cells Affecting Forelimb Muscles in Behaving Primates

被引:21
作者
Smith, W. S.
Fetz, E. E. [1 ]
机构
[1] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA
基金
美国国家卫生研究院;
关键词
SINGLE INTRACORTICAL MICROSTIMULI; SPIKE-TRIGGERED AVERAGES; MOTOR CORTEX; POSTSPIKE FACILITATION; EMG ACTIVITY; MONKEY; NEURONS; SYNCHRONY; UNITS;
D O I
10.1152/jn.91052.2008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Smith WS, Fetz EE. Synaptic linkages between corticomotoneuronal cells affecting forelimb muscles in behaving primates. J Neurophysiol 102: 1040-1048, 2009. First published June 10, 2009; doi: 10.1152/jn.91052.2008. To elucidate the cortical circuitry controlling primate forelimb muscles we investigated the synaptic interactions between neighboring motor cortex cells that had postspike output effects in target muscles. In monkeys generating isometric ramp-and-hold wrist torques, pairs of cortical cells were recorded simultaneously with independent electrodes and corticomotoneuronal ("CM") cells were identified by their postspike effects on target forelimb muscles in spike-triggered averages (SpTAs) of electromyographs (EMGs). The response patterns of the cells were determined in response-aligned averages and their synaptic interactions were identified by cross-correlograms of action potentials. The possibility that synchronized firing between cortical cells could mediate spike-correlated effects in the SpTA of EMG was examined in several ways. Sixty-two pairs consisted of one CM cell and a non-CM cell; 15 of these had correlogram peaks of the same magnitude as that of other pairs, but the synchrony peaks did not mediate any postspike effect from the non-CM cell. Twelve pairs of simultaneously recorded CM cells were cross-correlated. Half had features (usually synchrony peaks) in their cross-correlograms and the cells of these pairs also shared some target muscles in common. The other half had flat correlograms and, in most of these pairs, the CM cells affected different muscles. The latter group included pairs of CM cells that facilitated synergistic muscles. These results indicate that common synaptic input specifically affects CM cells that have overlapping muscle fields. Reconstruction of the cortical locations of CM cells affecting 12 different muscles showed a wide and overlapping distribution of cortical colonies of forelimb muscles.
引用
收藏
页码:1040 / 1048
页数:9
相关论文
共 24 条
[1]   Computer simulation of post-spike facilitation in spike-triggered averages of rectified EMG [J].
Baker, SN ;
Lemon, RN .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (03) :1391-1406
[2]   Corticomotoneuronal contribution to the fractionation of muscle activity during precision grip in the monkey [J].
Bennett, KMB ;
Lemon, RN .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) :1826-1842
[3]   SELECTIVE FACILITATION OF DIFFERENT HAND MUSCLES BY SINGLE CORTICOSPINAL NEURONS IN THE CONSCIOUS MONKEY [J].
BUYS, EJ ;
LEMON, RN ;
MANTEL, GWH ;
MUIR, RB .
JOURNAL OF PHYSIOLOGY-LONDON, 1986, 381 :529-549
[4]   COMPARABLE PATTERNS OF MUSCLE FACILITATION EVOKED BY INDIVIDUAL CORTICOMOTONEURONAL (CM) CELLS AND BY SINGLE INTRACORTICAL MICROSTIMULI IN PRIMATES - EVIDENCE FOR FUNCTIONAL-GROUPS OF CM CELLS [J].
CHENEY, PD ;
FETZ, EE .
JOURNAL OF NEUROPHYSIOLOGY, 1985, 53 (03) :786-804
[5]   Rapid changes in throughput from single motor cortex neurons to muscle activity [J].
Davidson, Adam G. ;
Chan, Vanessa ;
O'Dell, Ryan ;
Schieber, Marc H. .
SCIENCE, 2007, 318 (5858) :1934-1937
[6]  
FETZ E, 1991, CEREB CORTEX, V9, P1
[7]   Roles of primate spinal interneurons in preparation and execution of voluntary hand movement [J].
Fetz, EE ;
Perlmutter, SI ;
Prut, Y ;
Seki, K ;
Votaw, S .
BRAIN RESEARCH REVIEWS, 2002, 40 (1-3) :53-65
[8]   POSTSPIKE FACILITATION OF FORELIMB MUSCLE-ACTIVITY BY PRIMATE CORTICOMOTONEURONAL CELLS [J].
FETZ, EE ;
CHENEY, PD .
JOURNAL OF NEUROPHYSIOLOGY, 1980, 44 (04) :751-772
[9]   Do corticomotoneuronal cells predict target muscle EMG activity? [J].
Griffin, D. M. ;
Hudson, H. M. ;
Belhaj-Saif, A. ;
McKiernan, B. J. ;
Cheney, P. D. .
JOURNAL OF NEUROPHYSIOLOGY, 2008, 99 (03) :1169-1186
[10]   Synchrony between neurons with similar muscle fields in monkey motor cortex [J].
Jackson, A ;
Gee, VJ ;
Baker, SN ;
Lemon, RN .
NEURON, 2003, 38 (01) :115-125