Nosylaziridines: Activated aziridine electrophiles

被引：124

作者：

Maligres, PE

See, MM

Askin, D

Reider, PJ

机构：

[1] Department of Process Research, Merck Research Laboratories, Merck and Co. Inc., Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(97)01157-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can be readily cleaved under mild conditions to provide the primary amines. (C) 1997 Elsevier Science Ltd.

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页码：5253 / 5256

页数：4

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