Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors

被引：482

作者：

Butler, Jason M. ^{[1
]}

Kobayashi, Hideki ^{[1
]}

Rafii, Shahin ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Dept Med Genet, Ansary Stem Cell Inst, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 02期

关键词：

ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE SYNTHASE; HUMAN-MELANOMA CELLS; LEUKEMIC STEM-CELLS; HEMATOPOIETIC STEM; ANGIOGENIC SWITCH; PHENOTYPIC HETEROGENEITY; ANTIANGIOGENIC THERAPY; PERIVASCULAR NICHE; BASEMENT-MEMBRANE;

D O I：

10.1038/nrc2791

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O-2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.

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收藏

页码：138 / 146

页数：9

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