Pathological aspects of apoptosis in severe sepsis and shock?

被引：44

作者：

Ayala, A ^{[1
]}

Lomas, JL ^{[1
]}

Grutkoski, PS ^{[1
]}

Chung, CS ^{[1
]}

机构：

[1] Brown Univ, Rhode Isl Hosp, Sch Med, Div Surg Res,Dept Surg, Providence, RI 02903 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2003年 / 35卷 / 01期

关键词：

lymphocyte; macrophage; neutrophil; cell death receptors; mitochondria; cytokines; mediators;

D O I：

10.1016/S1357-2725(02)00099-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Today, despite the application of contemporary operative/pharmacological approaches in the treatment of the critically ill trauma/surgery patient, we are still faced with a high incidence of patients who develop sepsis and subsequent multiple organ failure. This review attempts to summarize data gathered over the last few years, from both experimental and patient settings, that not only documents the presence of apoptosis, but begins to define its contribution to the pathology of sepsis and shock, which in turn precipitate organ injury/damage. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7 / 15

页数：9

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