Bcl-2 completely blocks Fas-mediated apoptosis in mtDNA-depleted HeLa cells

被引：11

作者：

Asoh, S ^{[1
]}

Ohta, S ^{[1
]}

机构：

[1] NIPPON MED COLL,INST GERONTOL,DEPT BIOCHEM & CELL BIOL,NAKAHARA KU,KAWASAKI,KANAGAWA 211,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 237卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.7210

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Bcl-2 inhibits apoptosis induced by a variety of death stimuli but does not completely inhibit Fas-mediated apoptosis. We have previously shown that a HeLa-derived cell line lacking mitochondrial DNA (mtDNA) expresses Fas at a high level and apoptosis is easily induced using a low concentration of an anti-Fas antibody. In this study, overexpression of BcI-2 in the mtDNA-less cells completely blocked Fas-mediated apoptosis, and this was not due to a depression of the enhanced Fas expression. These findings suggest that the Fas-mediated apoptotic pathway is directly linked to Bcl-2 protection in the cells with an accompanying mitochondrial dysfunction. (C) 1997 Academic Press.

引用

页码：659 / 662

页数：4

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