The road to chromatin - nuclear entry of retroviruses

被引：201

作者：

Suzuki, Youichi

Craigie, Robert ^{[1
]}

机构：

[1] NIDDKD, Lab Mol Biol, NIH, Bethesda, MD 20892 USA

[2] Kyoto Univ, Lab Host Factors, Ctr Emerging Virus Res, Inst Virus Res,Sakyo Ku, Kyoto 6068507, Japan

来源：

NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrmicro1579

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA copy of their genome after entry into the host cell. Integration of this DNA into the host cell's genome is an essential step in the viral replication cycle. The viral DNA is synthesized in the cytoplasm and is associated with viral and cellular proteins in a large nucleoprotein complex. Before integration into the host genome can occur, this complex must be transported to the nucleus and must cross the nuclear envelope. This Review summarizes our current knowledge of how this journey is accomplished.

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页码：187 / 196

页数：10

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