Glyceroneogenesis comes of age

被引:55
作者
Beale, EG
Hammer, RE
Antoine, B
Forest, C
机构
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA
[2] Ctr Univ UFR Biomed, F-75006 Paris, France
[3] Univ Paris 05, INSERM, U530, Unite Mixte, F-75270 Paris 06, France
[4] Univ Texas, SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75235 USA
[5] Univ Texas, SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75235 USA
关键词
phosphoenolpyruvate carboxykinase; lipid homeostasis; obesity; diabetes;
D O I
10.1096/fj.02-0407rev
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Glyceroneogenesis is a generally ignored metabolic pathway that occurs in adipose tissues and liver of mammalian species. This short review highlights a series of recent discoveries showing that glyceroneogenesis is important in lipid homeostasis.
引用
收藏
页码:1695 / 1696
页数:2
相关论文
共 12 条
[1]
BALLARD FJ, 1967, J BIOL CHEM, V242, P2746
[2]
Glucose contribution to in vivo synthesis of glyceride-glycerol and fatty acids in rats adapted to a high-protein, carbohydrate-free diet [J].
Botion, LM ;
Brito, MN ;
Brito, NA ;
Brito, SRC ;
Kettelhut, IC ;
Migliorini, RH .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (10) :1217-1221
[3]
Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor γ and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo [J].
Devine, JH ;
Eubank, DW ;
Clouthier, DE ;
Tontonoz, P ;
Spiegelman, BM ;
Hammer, RE ;
Beale, EG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) :13604-13612
[4]
Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance [J].
Franckhauser, S ;
Muñoz, S ;
Pujol, A ;
Casellas, A ;
Riu, E ;
Otaegui, P ;
Su, BL ;
Bosch, F .
DIABETES, 2002, 51 (03) :624-630
[5]
A single element in the phosphoenolpyruvate carboxykinase gene mediates thiazolidinedione action specifically in adipocytes [J].
Glorian, M ;
Duplus, E ;
Beale, EG ;
Scott, DK ;
Granner, DK ;
Forest, C .
BIOCHIMIE, 2001, 83 (10) :933-943
[6]
GLYCERONEOGENESIS IN ADIPOSE TISSUE OF FASTED DIABETIC AND TRIAMCINOLONE TREATED RATS [J].
GORIN, E ;
TALOR, Z ;
SHAFRIR, E .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1969, 8 (03) :370-&
[7]
Glyceroneogenesis and the source of glycerol for hepatic triacylglycerol synthesis in humans [J].
Kalhan, SC ;
Mahajan, S ;
Burkett, E ;
Reshef, L ;
Hanson, RW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) :12928-12931
[8]
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes [J].
Lewis, GF ;
Carpentier, A ;
Adeli, K ;
Giacca, A .
ENDOCRINE REVIEWS, 2002, 23 (02) :201-229
[9]
A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice [J].
Olswang, Y ;
Cohen, H ;
Papo, O ;
Cassuto, H ;
Croniger, CM ;
Hakimi, P ;
Tilghman, SM ;
Hanson, RW ;
Reshef, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :625-630
[10]
RESHEF L, 1969, J BIOL CHEM, V244, P1994