Synthesis and evaluation of water-soluble paclitaxel prodrugs

被引：46

作者：

Feng, X ^{[1
]}

Yuan, YJ ^{[1
]}

Wu, JC ^{[1
]}

机构：

[1] Tianjin Univ, Dept Pharmaceut Engn, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 22期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(02)00694-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of water-soluble 2'-paclitaxel prodrugs were synthesized by attaching paclitaxel to polyethylene glycol (PEG) through amino acid spacers. The prodrugs showed highly improved water solubility, enhanced in vitro cytotoxicity and in vivo antitumor activity compared with the native drug, paclitaxel. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3301 / 3303

页数：3

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