Measurement and Modulation of Plasticity of the Motor System in Humans Using Transcranial Magnetic Stimulation

被引：47

作者：

Chen, Robert ^{[1
,2
]}

Udupa, Kaviraja ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[2] Toronto Western Res Inst, Div Brain Imaging & Behav Syst Neurosci, Toronto, ON, Canada

来源：

MOTOR CONTROL | 2009年 / 13卷 / 04期

关键词：

transcranial magnetic stimulation; synaptic plasticity; long term potentiation; depression; THETA-BURST-STIMULATION; PAIRED ASSOCIATIVE STIMULATION; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; CORTEX EXCITABILITY; CORTICAL PLASTICITY; PREFRONTAL CORTEX; HIGH-FREQUENCY; LTP; DEPRESSION;

D O I：

10.1123/mcj.13.4.442

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Several techniques that involve transcranial magnetic stimulation (TMS) can be used to measure brain plasticity noninvasively in humans. These include paired-associative stimulation (PAS), repetitive transcranial magnetic stimulation (rTMS) and theta burst stimulation (TBS). Some of these techniques are based the principle of use dependent plasticity or are designed to mimic protocols used to induce long-term potentiation or depression in animal studies. These studies have been applied to certain neurological and psychiatric disorders to investigate their pathophysiology. For example, PAS induced plasticity is enhanced in dystonia and stroke but is reduced in Huntington's disease and schizophrenia. Furthermore, TMS may be used to modulate brain plasticity and has therapeutic potential in neurological and psychiatric disorders such as stroke, Parkinson's disease, dystonia and depression.

引用

页码：442 / 453

页数：12

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