Expression of angiotensin II AT2 receptor in the acute phase of stroke in rats

被引：55

作者：

Zhu, YZ

Chimon, GN

Zhu, YC

Lu, Q

Li, B

Hu, HZ

Yap, EH

Lee, HS

Wong, PTH

机构：

[1] Natl Univ Singapore, Fac Med, Dept Pharmacol, Singapore 119260, Singapore

[2] Natl Univ Singapore, Fac Med, Dept Microbiol, Singapore 119260, Singapore

[3] Shanghai Med Univ, Dept Physiol, State Key Lab Neurosci, Shanghai 200032, Peoples R China

来源：

NEUROREPORT | 2000年 / 11卷 / 06期

关键词：

angiotensin II receptor; cerebral ischemia; gene expression; polymerase chain reaction; stroke;

D O I：

10.1097/00001756-200004270-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A male Wistar rat model of stroke (middle cerebral artery occlusion; MCAO) was used to study the angiotensin II (Ang II) receptor subtype 2 (AT(2)) gene expression by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical staining. After permanent occlusion of the middle cerebral artery (MCA), AT2 receptor gene expression was found to increase in the infarct cortex by 2.7-fold (1 day) and 1.7-fold (3 days), respectively. Positive AT(2) immunostaining was also observed in the infarct area of the cerebral cortex. Apoptotic markers were detected in the necrotic area of the stroke cerebral cortex 1 day after MCAO. This demonstrated up-regulation of AT2 receptor may be involved in the apoptosis of tissue repair after stroke. NeuroReport 11:1191-1194 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：1191 / 1194

页数：4

共 15 条

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