The transcription of NAM7/UPF1 is enhanced in the absence of Cyp1p/Hap1p concomitant with the appearance of an ISF1-NAM7 cotranscript in Saccharomyces cerevisiae

被引:1
作者
Altamura, N [1 ]
dePinto, B [1 ]
Castaldo, R [1 ]
Verdiere, J [1 ]
机构
[1] UNIV PARIS 06,CTR GENET MOL,CNRS,LAB PROPRE ASSOCIE,F-91198 GIF SUR YVETTE,FRANCE
关键词
mitochondrial function; nuclear gene; CYP1(HAP1); cotranscription; transcriptional regulation;
D O I
10.1016/S0014-5793(97)00497-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The two adjacent nuclear genes ISF1 and NAM7 cooperatively participate in mitochondrial functions, It is well known that Cyp1p(Hap1p) activates a number of genes involved in these same functions, We show in this paper that Cyp1p influences the transcriptional regulation of NAM7, In addition, a significant amount of ISF1-NAM7 cotranscript is observed in a cyp1 mutant context, An extensive analysis of the intergenic region which separates the two genes revealed 5' starts of the NAM7 transcripts, additional to those previously mapped, These new 5' starts overlap the 3' ends of ISF1. We propose that NAM7 is under the control of a negative Cyp1p-dependent regulator and that its absence favours a transcriptional readthrough which results in the ISF1-NAM7 cotranscript we have identified. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码:96 / 100
页数:5
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