Monoterpenoid Indole Alkaloids from Alstonia yunnanensis

被引：68

作者：

Feng, Tao ^{[1
,2
]}

Li, Yan ^{[1
]}

Cai, Xiang-Hai ^{[1
]}

Gong, Xun ^{[1
]}

Liu, Ya-Ping ^{[1
,2
]}

Zhang, Rong-Ting ^{[1
,2
]}

Zhang, Xiang-Yun ^{[1
,2
]}

Tan, Qin-Gang ^{[1
,2
]}

Luo, Xiao-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 10期

关键词：

ABSOLUTE STEREOCHEMISTRY; VENENATA RBR; LEAVES; 19-EPIAJMALICINE; RAUCAFFRINOLINE; PROLIFERATION; LOCHNERICINE; SCHOLARIS; PLANTS;

D O I：

10.1021/np900374s

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of. the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC50 = 3.89 mu M) and hepatocellular carcinoma SMMC-7721 (IC50 = 21.73 mu M) cell lines.

引用

页码：1836 / 1841

页数：6

共 39 条

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