The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses

被引：89

作者：

Barouch, DH

Letvin, NL

Seder, RA

机构：

[1] NIAID, Cellular Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[2] Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02215 USA

来源：

IMMUNOLOGICAL REVIEWS | 2004年 / 202卷

关键词：

D O I：

10.1111/j.0105-2896.2004.00200.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines represent a diverse group of immunologic effector and regulatory proteins that are critical components of the host response to invading pathogens. They have also been utilized as adjuvants to enhance immune responses to vaccines. In particular, plasmid cytokines have been studied extensively as candidate adjuvants for DNA vaccines in preclinical models and are now entering early-phase clinical trials. Here, we review recent advances in our understanding of cytokine biology, T-lymphocyte differentiation, and potential applications of plasmid cytokines in the rational design of improved vaccines.

引用

页码：266 / 274

页数：9

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