Selective cytotoxicity of certain 9-substituted ellipticines for leukemia cells in a variety of leukemia cell cultures

被引：6

作者：

Devraj, R ^{[1
]}

Cushman, M ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT MED CHEM & MOL PHARMACOL,W LAFAYETTE,IN 47907

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(97)00021-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Certain 9-substituted ellipticines, including 9-hydroxymethylellipticine, displayed selective in vitro cytotoxicity for leukemia cells in a variety of leukemia cell cultures. The selective cytotoxicity was apparent in all of the leukemia cell lines examined, which included CCRF-CEM, HL-60 (TB), K-562, MOLT-4, RPMI-8226, and SR cells. (C) 1997, Elsevier Science Ltd.

引用

页码：369 / 372

页数：4

共 8 条

[1] ANTICANCER SPECIFICITY OF SOME ELLIPTICINIUM SALTS AGAINST HUMAN BRAIN-TUMORS IN-VITRO [J].

ACTON, EM ;

NARAYANAN, VL ;

RISBOOD, PA ;

SHOEMAKER, RH ;

VISTICA, DT ;

BOYD, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (14) :2185-2189

[2]

ACTON EM, 1992, P 83 ANN M AM ASS CA, P488

[3] DESIGN, SYNTHESIS, AND STUDY OF 9-SUBSTITUTED ELLIPTICINE AND 2-METHYLELLIPTICINIUM ANALOGS AS POTENTIAL CNS-SELECTIVE ANTITUMOR AGENTS [J].

ANDERSON, WK ;

GOPALSAMY, A ;

REDDY, PS .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (13) :1955-1963

[4]

Boyd M. R., 1989, CANCER PRINCIPLES PR, V3, P1

[5] DESIGN AND SYNTHESIS OF ELLIPTICINIUM SALTS AND 1,2-DIHYDROELLIPTICINES WITH HIGH SELECTIVITIES AGAINST HUMAN CNS CANCERS IN-VITRO [J].

JURAYJ, J ;

HAUGWITZ, RD ;

VARMA, RK ;

PAULL, KD ;

BARRETT, JF ;

CUSHMAN, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (14) :2190-2197

[6] FEASIBILITY OF A HIGH-FLUX ANTICANCER DRUG SCREEN USING A DIVERSE PANEL OF CULTURED HUMAN TUMOR-CELL LINES [J].

MONKS, A ;

SCUDIERO, D ;

SKEHAN, P ;

SHOEMAKER, R ;

PAULL, K ;

VISTICA, D ;

HOSE, C ;

LANGLEY, J ;

CRONISE, P ;

VAIGROWOLFF, A ;

GRAYGOODRICH, M ;

CAMPBELL, H ;

MAYO, J ;

BOYD, M .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (11) :757-766

[7] DISPLAY AND ANALYSIS OF PATTERNS OF DIFFERENTIAL ACTIVITY OF DRUGS AGAINST HUMAN-TUMOR CELL-LINES - DEVELOPMENT OF MEAN GRAPH AND COMPARE ALGORITHM [J].

PAULL, KD ;

SHOEMAKER, RH ;

HODES, L ;

MONKS, A ;

SCUDIERO, DA ;

RUBINSTEIN, L ;

PLOWMAN, J ;

BOYD, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (14) :1088-1092

[8]

PLUG JPM, 1992, SYNTHESIS-STUTTGART, P1221

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