STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor

被引：226

作者：

Pfeffer, LM

Mullersman, JE

Pfeffer, SR

Murti, A

Shi, W

Yang, CH

机构：

[1] Department of Pathology, University of Tennessee, Health Science Center, Memphis

来源：

SCIENCE | 1997年 / 276卷 / 5317期

关键词：

D O I：

10.1126/science.276.5317.1418

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

STAT (signal transducers and activators of transcription) proteins undergo cytokine-dependent phosphorylation on serine and tyrosine, STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor. STAT3 bound to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and underwent interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol S-kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subsequently underwent tyrosine phosphorylation, Thus, STAT3 acts as an adapter to couple another signaling pathway to the interferon receptor.

引用

收藏

页码：1418 / 1420

页数：3

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