Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure

被引：70

作者：

Hirose, Takuo ^{[1
]}

Mori, Nobuyoshi ^{[2
]}

Totsune, Kazuhito ^{[1
,3
]}

Morimoto, Ryo ^{[4
]}

Maejima, Takahiro ^{[5
]}

Kawamura, Takuya ^{[1
]}

Metoki, Hirohito ^{[1
,6
]}

Asayama, Kei ^{[3
]}

Kikuya, Masahiro ^{[1
]}

Ohkubo, Takayoshi ^{[3
,5
]}

Kohzuki, Masahiro ^{[2
]}

Takahashi, Kazuhiro ^{[7
]}

Imai, Yutaka ^{[1
,3
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Clin Pharmacol & Therapeut, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Internal Med & Rehabil Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

[3] Tohoku Univ, 21st Century Ctr, Excellence Program Comprehens Res & Educ Ctr Plan, Aoba Ku, Sendai, Miyagi 9808578, Japan

[4] Tohoku Univ, Grad Sch Med, Div Nephrol Endocrinol & Vasc Med, Dept Med,Aoba Ku, Sendai, Miyagi 9808578, Japan

[5] Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Planning Drug Dev & Clin Evaluat, Aoba Ku, Sendai, Miyagi 9808578, Japan

[6] Tohoku Univ, Grad Sch Med, Dept Med Genet, Aoba Ku, Sendai, Miyagi 9808578, Japan

[7] Tohoku Univ, Grad Sch Med, Dept Endocrinol & Appl Med Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

PEPTIDES | 2009年 / 30卷 / 12期

基金：

日本学术振兴会;

关键词：

Renin-angiotensin system; Organ damage; RT-PCR; Immunohistochemistry; RENIN-ANGIOTENSIN SYSTEM; NONPROTEOLYTIC ACTIVATION; RENIN/PRORENIN RECEPTOR; BLOOD-PRESSURE; PRORENIN; PEPTIDE; INCREASES; BLOCKADE; BINDING; GLOMERULOSCLEROSIS;

D O I：

10.1016/j.peptides.2009.09.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, was associated with organ damage in the kidney. However, there has been little information for (P)RR in hearts. To investigate the regulation of (P)RR in heart failure, we examined the expression of (P)RR in hearts and kidneys of rats with congestive heart failure (CHF) due to coronary ligation by quantitative RT-PCR and immunohistochemistry. Significantly increased levels of (P)RR mRNA were found in the atrium, right ventricle, non-infarcted part of left ventricle, infarcted part of left ventricle and kidney of CHF rats, when compared with sham operated rats (about 1.6-fold, 1.4-fold, 1.6-fold, 1.7-fold and 1.5-fold, respectively). Expression levels of mRNAs encoding renin and angiotensinogen in these heart and kidney tissues were also increased in the CHF rats. Immunohistochemistry showed positive (P)RR immunostaining in the myocardium, the renal tubular cells, and vascular smooth muscle and endothelial cells in the heart and the kidney. The renal tubular cells were more intensely immunostained in CHF rats than in sham operated rats. These findings suggest that the expression of (P)RR is increased in the hearts and kidneys of rats with heart failure, and that (P)RR may contribute to heart failure. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：2316 / 2322

页数：7

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