A total asymmetric synthesis of (-)-suaveoline

被引：20

作者：

Bailey, PD

Morgan, KM

机构：

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 12期

关键词：

D O I：

10.1039/cc9960001479

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new total synthesis of (-)-suaveoline from L-tryptophan is reported (overall yield ca. 14%); key steps include a high yielding cis-specific Pictet-Spengler reaction, a one-pot Horner-Wadsworth-Emmons/alkylation procedure, a vinylogous Thorpe cyclization and the direct formation of a pyridine from a 1,5-dinitrile.

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页码：1479 / 1480

页数：2

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