Receptor communication within the lymphocyte plasma membrane:: a role for the thrombospondin family of matricellular proteins

被引：17

作者：

Forslow, A. ^{[1
]}

Liu, Z. ^{[1
]}

Sundqvist, K. -G. ^{[1
]}

机构：

[1] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Div Clin Immunol,Dept Lab Med, SE-14186 Stockholm, Sweden

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 01期

关键词：

thrombospondin; lymphocyte; extracellular matrix; adhesion; integrin-associated protein; antigen-presenting cell;

D O I：

10.1007/s00018-006-6255-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lymphocytes, the principal cells of the immune system, carry out immune surveillance throughout the body by their unique capacity to constantly reposition themselves between a free-floating vascular state and a tissue state characterized by migration and frequent adhesive interactions with endothelial cells and components of the extracellular matrix. Therefore, mechanisms co-ordinating adhesion and migration with signals delivered through antigen recognition probably play a pivotal role for the regulation of lymphocyte behaviour and function. Endogenous thrombospondin-1 (TSP-1) seems to be the hub in such a mechanism for autocrine regulation of T cell adhesion and migration. TSP-1 functions as a mediator of cis interaction of vital receptors within the T lymphocyte plasma membrane, including integrins, low density lipoprotein receptor-related protein, calreticulin and integrin-associated protein.

引用

页码：66 / 76

页数：11

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