Synthesis of (difluoromethyl)phosphonate azasugars designed as inhibitors for glycosyl transferases

被引：41

作者：

Behr, JB ^{[1
]}

Evina, CM ^{[1
]}

Phung, N ^{[1
]}

Guillerm, G ^{[1
]}

机构：

[1] UNIV REIMS,CNRS,CHIM BIOORGAN LAB,UFR SCI,F-51687 REIMS 2,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 11期

关键词：

D O I：

10.1039/a700800g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyhydroxylated pyrrolidines (azasugars) bearing a (difluoromethylene)phosphonate group at the pseudoanomeric position are prepared by nucleophilic opening of arabino-, ribo- and xylo-furanosylamine with diethyl (lithiodifluoromethyl)phosphonate followed by cyclisation of the amino phosphonate products obtained.

引用

页码：1597 / 1599

页数：3

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