Circulating levels of TNF-α and its soluble receptors in the plasma of patients with epithelial ovarian cancer

被引：39

作者：

Dobrzycka, Bozena ^{[1
]}

Terlikowski, Slawomir J. ^{[1
]}

Kowalczuk, Oksana ^{[2
]}

Kinalski, Maciej ^{[3
]}

机构：

[1] Med Univ Bialystok, Dept Gynecol & Obstetr Nursing, PL-15062 Bialystok, Poland

[2] Med Univ Bialystok, Dept Clin Mol Biol, PL-15062 Bialystok, Poland

[3] Dist Hosp Bialystok, Dept Gynecol, Bialystok, Poland

来源：

EUROPEAN CYTOKINE NETWORK | 2009年 / 20卷 / 03期

关键词：

tumor necrosis factor-alpha; soluble tumor necrosis factor receptor 1; soluble tumor necrosis factor receptor 2; plasma; epithelial ovarian cancer; NECROSIS-FACTOR-ALPHA; INFLAMMATION; SERUM;

D O I：

10.1684/ecn.2009.0161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The significance of circulating levels of TNF-alpha and its soluble receptors (sTNF-Rs) in the plasma of patients with epithelial ovarian cancer (EOC) has not been fully elucidated. The present study was to investigate the relationship of pretreatment plasma levels of TNF-alpha, sTNFR-1 and sTNFR-2 with outcome in 126 patients with EOC. Concentrations of TNF-alpha and sTNF-Rs were determined by enzyme-linked immunosorbent assay (ELISA). Median TNF-alpha and sTNF-Rs levels were significantly higher in EOC patients than in healthy controls. High plasma levels of TNF-alpha and sTNF-Rs were correlated with tumor stage and with reduced mean survival time (MST). The results of the present study suggested that preoperative plasma TNF-alpha and sTNF-Rs levels in EOC patients correlated with the highest risk of cancer progression. Thus, the clinical value of an activated TNF system in EOC needs to be further investigated.

引用

页码：131 / 134

页数：4

共 21 条

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