Cerebrovascular pathology and dementia in autopsied Honolulu-Asia aging study participants

被引:274
作者
White, L
Petrovitch, H
Hardman, J
Nelson, J
Davis, DG
Ross, GW
Masaki, K
Launer, L
Markesbery, WR
机构
[1] PHRI, Honolulu, HI 96813 USA
[2] Kuakini Med Ctr, Honolulu, HI USA
[3] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA
[4] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA
[5] Univ Kentucky, Dept Pathol & Lab Med, Lexington, KY USA
[6] Dept Vet Affairs, Honolulu, HI USA
[7] NIA, NIH, Bethesda, MD 20892 USA
来源
ALZHEIMER'S DISEASE: VASCULAR ETIOLOGY AND PATHOLOGY | 2002年 / 977卷
关键词
dementia; cognitive impairment; aging; pathology; microinfarct; brain; Alzheimer; vascular dementia;
D O I
10.1111/j.1749-6632.2002.tb04794.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Clinicopathologic data from 285 autopsies were analyzed. The decedents were long-standing participants in the Honolulu-Asia Aging Study, a prospective epidemiologic investigation of stroke, neurodegenerative diseases, and aging. We assessed the prevalence at death of four primary neuropathologic processes using specific microscopic lesions as indicators. An algorithm was developed to assign each decedent to one of six subsets, corresponding to pathologic dominance by microvascular lesions (14% of decedents), Alzheimer lesions (12%), hippocampal sclerosis (5%), cortical Lewy bodies (5%), codominance by two or more primary processes (9%), or without a dominant pathologic process recognized (55%). Definite or probable dementia had been identified in 118 of the decedents. The proportions of men in each subset identified as demented were (in the same order) 57%, 53%, 79%, 57%, 76%, and 25%. In this autopsied panel of older Japanese-American men, the importance of microvascular lesions as a likely explanation for dementia was nearly equal to that of Alzheimer lesions. The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction.
引用
收藏
页码:9 / 23
页数:15
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