Transcription factors in myeloid development: balancing differentiation with transformation

被引：491

作者：

Rosenbauer, Frank

Tenen, Daniel G.

机构：

[1] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

[2] Harvard Univ, Sch Med, Harvard Inst Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of the myeloid lineage. Transcription factors have been shown to be key determinants in the orchestration of myeloid identity and differentiation fates. Most transcription factors show cell-lineage-restricted and stage-restricted expression patterns, indicating the requirement for tight regulation of their activities. Moreover, if dysregulated or mutated, these transcription factors cause the differentiation block observed in many myeloid leukaemias. Consequently, therapies designed to restore defective transcription factor functions are an attractive option in the treatment of myeloid and other human cancers.

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收藏

页码：105 / 117

页数：13

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