Involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion after testicular ischemia in a rat model

被引：29

作者：

Sukhotnik, Igor ^{[1
]}

Voskoboinik, Katya ^{[1
]}

Lurie, Michael ^{[2
]}

Bejar, Yakov ^{[2
]}

Coran, Arnold G. ^{[3
,4
]}

Mogilner, Jorge G. ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Pediat Surg, Haifa, Israel

[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Bnai Zion Med Ctr, IL-31096 Haifa, Israel

[3] Univ Michigan, CS Mott Childrens Hosp, Pediat Surg Sect, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Sch Med, Ann Arbor, MI USA

来源：

FERTILITY AND STERILITY | 2009年 / 92卷 / 04期

关键词：

CONTRALATERAL TESTIS; TORSION; MICE; PATHWAY; DEATH;

D O I：

10.1016/j.fertnstert.2009.04.026

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

The objective of this study was to examine the relationship between time of reperfusion and bax/bcl-2-dependent germ cell apoptosis after testicular ischemia-reperfusion injury in the rat. In ischemic testis, bax/bcl-2 ratio did not change significantly, and the elevation of germ cell apoptosis was not marked; in the contralateral testis, germ cell apoptosis increased after 6 hours of reperfusion, achieved statistical significance after 24 hours, and decreased after 72 hours of reperfusion and was initiated by decreased bcl-2 messenger RNA levels and elevated bax/bcl-2 ratio within the first 6 hours of reperfusion. (Fertil Steril (R) 2009;92:1466-9. (C) 2009 by American Society for Reproductive Medicine.)

引用

页码：1466 / 1469

页数：4

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