Trigeminovascular stimulation in conscious rats

被引：16

作者：

Kemper, RHA ^{[1
]}

Meijler, WJ ^{[1
]}

TerHorst, GJ ^{[1
]}

机构：

[1] UNIV GRONINGEN HOSP,DEPT ANAESTHESIOL,PAIN CTR,NL-9713 EZ GRONINGEN,NETHERLANDS

来源：

NEUROREPORT | 1997年 / 8卷 / 05期

关键词：

behaviour; animal; capsaicin; headache; migraine; pain; proto-oncogene protein c-fos; trigeminal caudal nucleus;

D O I：

10.1097/00001756-199703240-00012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

INTRACISTERNAL infusion of capsaicin was used to induce intracranial trigeminovascular stimulation in conscious rats. Both behaviour and trigeminal nucleus caudalis c-fos expression were examined. Exploratory behaviour was dose-dependently reduced and different types of behaviours were induced with various doses of capsaicin. Head grooming and scratching show that intracranial activation of trigeminal afferents can be referred as extracranial trigeminal stimulation. Analysis of behaviour exhibited during trigeminovascular stimulation may provide a powerful tool to study effects of central acting anti-migraine drugs.

引用

页码：1123 / 1126

页数：4

共 21 条

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