Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs

被引：9

作者：

Mauri, Claudia ^{[1
]}

Carter, Natalie ^{[1
]}

机构：

[1] UCL, Dept Med, Ctr Rheumatol Res, London W1 4JF, England

来源：

ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 04期

关键词：

COLLAGEN-INDUCED ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CD4; T-CELLS; TOLEROGENIC DENDRITIC CELLS; NECROSIS-FACTOR-ALPHA; ZONE B-CELLS; RHEUMATOID-ARTHRITIS; ORAL TOLERANCE; TGF-BETA; AUTOIMMUNE ENCEPHALOMYELITIS;

D O I：

10.1186/ar2752

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nature has provided the developing immune system with several checkpoints important for the maintenance of tolerance and the prevention of autoimmunity. The regulatory mechanisms operating in the periphery of the system are mediated by subsets of regulatory cells, now considered principal contributors to peripheral tolerance. Regulatory T cells (Tregs) have received titanic interest in the past decade, placing them at the centre of immunosuppressive reactions. However, it has become clearer that other immune suppressive cells inhibit auto-reactivity as effectively as Tregs. The function of Tregs and other regulatory cells in rheumatoid arthritis will be discussed in this review.

引用

页数：8

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