Advances in quantitative proteomics using stable isotope tags

被引：64

作者：

Flory, MR ^{[1
]}

Griffin, TJ ^{[1
]}

Martin, D ^{[1
]}

Aebersold, R ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2002年 / 20卷 / 12期

关键词：

D O I：

10.1016/S1471-1931(02)00203-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A great deal of current biological and clinical research is directed at the interpretation of the information contained in the human genome sequence in terms of the structure, function and control of biological systems and processes. Proteomics, the systematic analysis of proteins, is becoming a critical component in this endeavor because proteomic measurements are carried out directly on proteins - the catalysts and effectors of essentially all biological functions. To detect changes in protein profiles that might provide important diagnostic or functional insights, proteomic analyses necessarily have to be quantitative. This article summarizes recent technological advances in quantitative proteomics.

引用

页码：S23 / S29

页数：7

共 49 条

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