The use of plants in traditional medicine: potential genotoxic risks

被引：22

作者：

Elgorashi, EE ^{[1
]}

Taylor, JLS ^{[1
]}

Maes, A ^{[1
]}

de Kimpe, N ^{[1
]}

van Staden, J ^{[1
]}

Verschaeve, L ^{[1
]}

机构：

[1] Vlaamse Instelling Technol Onderzoek, Flemish Inst Technol Res, Div Environm Toxicol, B-2400 Mol, Belgium

来源：

SOUTH AFRICAN JOURNAL OF BOTANY | 2002年 / 68卷 / 03期

关键词：

D O I：

10.1016/S0254-6299(15)30409-9

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Dichloromethane and 90% methanol extracts of different parts of Antidesma venosum, Balanites maughamii, Chaetacme aristata, Croton sylvaticus, Gardenia volkensii, Plumbago auriculata and Spirostachys africana which are commonly used in South African traditional medicine were evaluated for their mutagenic potential. The genotoxicity tests used were the Ames test, micronucleus test, comet assay and VITOTOX(R) test. All species showed mutagenicity or DNA damage in at least one test. The species, organ extracted, extraction solvent and the type of test used, (whether based on bacterial or human cells), could affect the induction of genotoxicity.

引用

页码：408 / 410

页数：3

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