Nickel-mediated amination chemistry.: Part 2:: Selective N-arylation or N,N′-diarylation of piperazine

被引：47

作者：

Brenner, E ^{[1
]}

Schneider, R ^{[1
]}

Fort, Y ^{[1
]}

机构：

[1] Univ Nancy 1, Fac Sci, UMR CNRS UHP 7565, F-54506 Vandoeuvre Nancy, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 16期

关键词：

nickel; arylamination; N-arylpiperazine; N; '-diarylpiperazine;

D O I：

10.1016/S0040-4039(00)00277-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 2,2'-bipyridine liganded Ni catalyst has revealed a good selectivity in the mono arylation of piperazine starting from aryl chlorides allowing a selective and efficient synthesis of N-arylpiperazines using stoichiometric amounts of reagents. The preparation of N,N'-diaryl substituted piperazines is also described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2881 / 2884

页数：4

共 35 条

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