Evaluation of alternative calculation methods for determining low-density lipoprotein cholesterol in hemodialysis patients

被引：8

作者：

Bairaktari, ET ^{[1
]}

Tzallas, C

Kalientzidou, M

Tselepis, AD

Siamopoulos, KC

Seferiadis, KI

Elisaf, MS

机构：

[1] Univ Ioannina, Univ Hosp, Sch Med, Biochem Lab, GR-45110 Ioannina, Greece

[2] Univ Ioannina, Univ Hosp, Sch Med, Dept Nephrol, GR-45110 Ioannina, Greece

[3] Univ Ioannina, Dept Chem, GR-45110 Ioannina, Greece

[4] Univ Ioannina, Univ Hosp, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece

来源：

CLINICAL BIOCHEMISTRY | 2004年 / 37卷 / 10期

关键词：

LDL-cholesterol calculation; Friedewald equation; apolipoprotein B method comparison; hemodialysis patients; small dense LDL;

D O I：

10.1016/j.clinbiochem.2003.10.018

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

objectives: To evaluate alternative equations for the estimation of low-density lipoprotein cholesterol (LDL-C) than the Friedewald equation in hemodialysis patients. Design and methods: The equations LDL-C = 0.41TC - 0.14TG + 0.66ApoB - 10.43 and LDL-C = 0.94TC - 0.94HDL-C - 0.19TG were evaluated in 86 patients and compared with the Friedewald equation and the ultracentrifugation procedure. Results: The alternative equations yield significantly lower bias than the Friedewald equation and are less affected by increased triglycerides (TG) levels. Conclusion: The alternative equations for LDL-C yield slightly better results than the Friedewald equation especially in hypertriglyceridemia. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：937 / 940

页数：4

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