Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy

被引：57

作者：

Benarroch, EE

Schmeichel, AM

Parisi, JE

机构：

[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Anat Pathol, Rochester, MN USA

来源：

NEUROLOGY | 2002年 / 59卷 / 06期

关键词：

D O I：

10.1212/WNL.59.6.944

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 +/- 2 vs 81 +/- 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 +/- 3 vs 47 +/- 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.

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页码：944 / 946

页数：3

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