The chaperonin folding machine

被引：101

作者：

Saibil, HR

Ranson, NA

机构：

[1] Univ London Birkbeck Coll, Sch Crystallog, London WC1E 7HX, England

[2] Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(02)02211-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chaperonins are versatile molecular machines that assist the folding of a wide range of substrate proteins. They harness an ATPase cycle to control access of non-native proteins to hydrophobic binding sites. ATP binding promotes large conformational changes that partially bury the hydrophobic sites and initiate the binding of a co-chaperonin, creating closed and open cavities. Non-native proteins progress towards the native fold during their confinement in these cavities, and are then released by the allosteric action of ATP.

引用

收藏

页码：627 / 632

页数：6

相关论文

共 37 条

[1] The 2.4 angstrom crystal structure of the bacterial chaperonin GroEL complexed with ATP gamma S [J].

Boisvert, DC ;

Wang, JM ;

Otwinowski, Z ;

Horwich, AL ;

Sigler, PB .

NATURE STRUCTURAL BIOLOGY, 1996, 3 (02) :170-177

[2] THE CRYSTAL-STRUCTURE OF THE BACTERIAL CHAPERONIN GROEL AT 2.8-ANGSTROM [J].

BRAIG, K ;

OTWINOWSKI, Z ;

HEGDE, R ;

BOISVERT, DC ;

JOACHIMIAK, A ;

HORWICH, AL ;

SIGLER, PB .

NATURE, 1994, 371 (6498) :578-586

[3] Dual function of protein confinement in chaperonin-assisted protein folding [J].

Brinker, A ;

Pfeifer, G ;

Kerner, MJ ;

Naylor, DJ ;

Hartl, FU ;

Hayer-Hartl, M .

CELL, 2001, 107 (02) :223-233

[4] A structural model for GroEL-polypeptide recognition [J].

Buckle, AM ;

Zahn, R ;

Fersht, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3571-3575

[5] The Hsp70 and Hsp60 chaperone machines [J].

Bukau, B ;

Horwich, AL .

CELL, 1998, 92 (03) :351-366

[6] THE ORIGINS AND CONSEQUENCES OF ASYMMETRY IN THE CHAPERONIN REACTION CYCLE [J].

BURSTON, SG ;

RANSON, NA ;

CLARKE, AR .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 249 (01) :138-152

[7] GroEL/GroES-mediated folding of a protein too large to be encapsulated [J].

Chaudhuri, TK ;

Farr, GW ;

Fenton, WA ;

Rospert, S ;

Horwich, AL .

CELL, 2001, 107 (02) :235-246

[8] Folding of malate dehydrogenase inside the GroEL-GroES cavity [J].

Chen, JW ;

Walter, S ;

Horwich, AL ;

Smith, DL .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (08) :721-728

[9] The crystal structure of a GroEL/peptide complex: Plasticity as a basis for substrate diversity [J].

Chen, LL ;

Sigler, PB .

CELL, 1999, 99 (07) :757-768

[10] LOCATION OF A FOLDING PROTEIN AND SHAPE CHANGES IN GROEL-GROES COMPLEXES IMAGED BY CRYOELECTRON MICROSCOPY [J].

CHEN, S ;

ROSEMAN, AM ;

HUNTER, AS ;

WOOD, SP ;

BURSTON, SG ;

RANSON, NA ;

CLARKE, AR ;

SAIBIL, HR .

NATURE, 1994, 371 (6494) :261-264

← 1 2 3 4 →